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Endogenous and Exogenous Stem Cells to Repair Hand Function in Cervical SCI

We will discuss the neuroplasticity of hand function after cervical spinal cord injury (SCI). This presentation unveils the intricate mechanisms of neural repair and explores innovative strategies for restoring movement and independence. We begin by highlighting the critical role of the corticospinal tract, the key pathway for hand control, and its influence on recovery outcomes [1]. Then, we will explore recent findings on how spinal cord's own stem cells, the ependymal cells, can repair damaged connections. Discover the paradoxical role of glutamate, a molecule with both destructive and regenerative properties, and how it can stimulate stem cell activity. Augmenting AMPA receptor signaling is a promising approach that may enhance stem cell migration and promote functional recovery [2]. Furthermore, we'll examine the use of engineered stem cells to rebuild damaged circuits and forge new connections, leading to remarkable improvements when combined with targeted rehabilitation. This presentation offers a compelling look at the future of SCI treatment, where stem cells and rehabilitation work synergistically to unlock the brain's hidden potential, forging new pathways and restoring hand function.