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Basic laws of probability, sample distributions. Introduction to statistical inference and applications. Prerequisite: or Corequisite: MATH 152 or 155 or 158. Students wishing an intuitive appreciation of a broad range of statistical strategies may wish to take STAT 100 first. Quantitative.

Modern molecular biological and recombinant nucleic acid methods will be covered. Examples are DNA and RNA isolation, plasmid preparation, restriction enzyme digestion, DNA cloning and polymerase chain reaction. Prerequisite: or corequisite: MBB 331 with a minimum grade of C-. Students with credit for BISC 357 may not take this course for further credit.

Contemporary techniques in biochemistry including protein purification, immunochemical methods, and lipid characterization. Prerequisite: MBB 231, with a minimum grade of C. Recommended: CHEM 215 and CHEM 286 precede MBB 309W. Writing.

The enzymes and intermediates of major catabolic and anabolic pathways. Their regulation and integration in health and disease states. Prerequisite: MBB 231, with a minimum grade of C.

Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, immune system, neuronal transmission and the signal transduction pathways that integrate them. Prerequisite: MBB 231, with a minimum grade of C.

The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction. Prerequisite: MBB 231, and BISC 202, with a minimum grade of C.

Laboratory methods in immunology. Focus on the vertebrate immune system and the molecular and cellular principles underlying immune recognition. Experimental methods designed to combine serology, biochemistry, molecular biology, cell biology and genetics as a basis for understanding immunological aspects of health and disease. Prerequisite: HSCI 326 or MBB 326, and one of BISC 303, BISC 357, MBB 308, or MBB 309W.

Introduction to physical biochemistry including thermodynamics, spectroscopic principles and applications, and molecular transport and interactions. The physical properties and structure determination of biomolecules will be emphasized. Prerequisite: MATH 152 (or 155), PHYS 121 (or 102, or 126, or 141), CHEM 122 (or 102), MBB 222 with a minimum grade of C.

An exploration of the fundamental aspects of proteins; their chemical and physical nature, their synthesis, stability and turnover, as well as their structure and function. Methods of protein analysis and structure determination will be presented. Prerequisite: MBB 222 with a minimum grade of C.

Introduction to the structure and function of the immune system and how this system protects against microbial infections. Innate immune responses, including the function of innate immune cells, receptors and complement. Adaptive immune responses, including the organization of lymphoid organs, development and function of T and B cells, and antibodies. Prerequisite: MBB 231 with a minimum grade of C. Students with credit for HSCI 426, MBB 426 or HSCI 326 may not take this course for further credit.

Major topics in genomics and bioinformatics, with integrated discussion of associated ethical/legal/social issues. An overview of laboratory and computer-based methods to study genomes, and their applications. Hands-on computer lab session providing an opportunity to use and experiment with bioinformatics software and databases utilized in genomics and bioinformatics research. Prerequisite: MBB 231, BISC 202 and either MBB 243 or 3 units of CMPT or equivalent, all with a minimum grade of C. Recommended: STAT 201 (or an equivalent statistics course) or STAT 270.

Aspects of developmental biology in the context of signal transduction pathways. The diverse mechanisms used in cell signalling and how the various approaches to the study of signal transduction in organismal development complement each other will be examined with an emphasis on current literature. Prerequisite: MBB 331 or BISC 302W with a minimum grade of C.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: Will be announced before the start of the term and will depend upon the nature of the topic offered.

Recent literature is examined for insights into the structure and properties of DNA and RNA, drawing on a variety of biochemical, chemical and molecular biological perspectives. Prerequisite: MBB 331 with a minimum grade of C.

A review of recent research on the structure, dynamics, function and biosynthesis of membranes, membrane lipids and proteins. Prerequisite: MBB 322 and MBB 309W with a minimum grade of C, MBB 324 as a pre or co-requisite.

Mechanistic principles for how protein molecules achieve diverse functions such as chemical catalysis and conformational switching. Students will learn to critique hypotheses about structural mechanisms, and to interpret the primary literature reporting on structural evidence from X-ray diffraction and spectroscopy. Prerequisite: MBB 323 or MBB 324, with a minimum grade of C.

Structure and function of molecules that mediate transport across membranes including channels, carriers, and pumps. Primary literature from the fields of biochemistry and physiology will be explored through lectures and independent study. Prerequisite: MBB 321, 322 and either MBB 323 or CHEM 360, with a minimum grade of C. Students who have taken MBB 420 under the same topic may not take this course for further credit.

Defects in the immunologic response to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Prerequisite: One of MBB 326, HSCI 326, MBB 426 or HSCI 426, with a minimum grade of C, or permission of the instructor. Students with credit for HSCI 427 cannot take MBB 427 for credit.

The molecular strategies that bacterial and viral pathogens use to colonize the human body and cause disease will be studied. Emphasis will be placed on the specific microbes and their virulence factors, secretion systems, toxins and surface adhesions. Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. Prerequisite: MBB 322 with a minimum grade of C.

RNA plays an important role in gene regulation. This course will explore recent primary literature studying the biochemistry of these processes. Prerequisite: MBB 331 with a minimum grade of C.

Analysis of mechanisms of protein, lipid, and nucleic acid delivery and transport within cells; processes of protein targeting, exocytosis, and endocytosis; molecular mechanisms of vesicle transport and membrane fusion; role in signal transduction and disease. Prerequisite: MBB 322 and MBB 331, with a minimum grade of C.

The cellular processes at the interface of cells and the environment will be explored in-depth. Through the use of lectures and group discussions and an emphasis on the primary literature, the focus will be on recent developments in molecular cell biology through the study of symbiosis and adaptation. Prerequisite: MBB 322 and 331, with a minimum grade of C.

Laboratory with accompanying lectures designed to give practical experience in advanced contemporary molecular biology techniques. Projects will involve recombinant gene and protein manipulations to investigate the dynamics of proteins within living cells. Prerequisite: MBB 308 and MBB 331, all with a minimum grade of C, or permission of instructor. Recommended: MBB 309W.

Emerging concepts in epithelial cell biology, including the establishment and maintenance of epithelial cell polarity and cell adhesion leading to the sculpting of developing organisms, roles in wound healing, birth defects and microbial defense, and insights into the maintenance of epithelia by stem cells will be explored. Prerequisite: MBB 331 or BISC 333, with a minimum grade of C.

Lectures and student presentations will cover the wide range of ways in which organisms (primarily eukaryotes) regulate gene expression along the pathway from DNA to protein. Prerequisite: MBB 331, with a minimum grade of C.

Recent advances in human molecular genetics including genome analysis, gene therapy, genetic testing, and studies of genetic disorders. Prerequisite: MBB 331, with a minimum grade of C.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Prerequisite: will depend upon the nature of the topic offered.

Examining the use of, and theory behind, bioinformatic software and algorithms for the analysis of macromolecular data. Includes consideration of recent literature and discussion of ethics in method development and analysis. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C.

A consideration of protein biogenesis (folding, assembly, and targeting to cellular compartments), modification, and degradation, and their roles in protein and cellular function. Prerequisite: MBB 321 and MBB 322, with a minimum grade of C.

An examination of the molecular mechanisms that contribute to tumor formation, the hallmarks of cancer and their relationship to therapeutic strategies. Prerequisite: MBB 322 and 331, with a minimum grade of C, or permission of the instructor.

The topics in this course will vary from term to term, depending on faculty availability and student interest. Students may repeat this course for further credit under a different topic. Prerequisite: Will vary depending on the topic.

Examination of the fundamentals of comparative genomics, identification and activity of functional elements in genomes, inter- and intra-species comparisons, relationship of genomic to phenotypic variation, and personalized genomics are among the topics to be explored. Comparison of genome data has impacts on medicine and many other fields of the life sciences. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students who have completed MBB 440 Comparative Genomics may not complete this course for further credit.

The organization of the human genome and the role of genomic variation in health and disease. Genomics and personalized medicine; intellectual property and privacy issues. Prerequisite: MBB 331 and MBB 342, with a minimum grade of C. Students with credit for MBB 440 with this same course title may not complete this course for further credit.

A focus on the molecular and genomic biology associated with forensic science, including genome structure, genotyping, genetic analysis of DNA fingerprints, DNA data bases and CODIS, Y STRs. mtDNA and ethical considerations of DNA typing. Prerequisite: MBB 331, with a minimum grade of C.

Methods that enable the integration of Biochemical, Genetic and Genomic knowledge (BiGG) to reconstruct a genomic scale network that defines the metabolic physiology of an organism will be explored. Applications of these approaches in the fields of microbial evolution, interaction networks, genetic engineering and drug discovery will be discussed. Prerequisite: MBB 331 and MBB 342.

MBB 481 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 481 encompasses the research design aspect of the project, consisting of the research proposal and honours thesis. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 482 and MBB 483.

MBB 482 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 482 encompasses the research performance aspect of the project. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 481 and MBB 483.

MBB 483 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 483 encompasses the defense component of the research project. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 481 and MBB 482.

MBB 491 is offered as a stand-alone Directed Research course open to MBB Majors, or as the first of two courses taken consecutively to fulfill the requirements of the MBB Honours program (Option B). This course provides students with the opportunity to carry out part time laboratory research in an area of molecular biology or biochemistry under the supervision of an MBB faculty member or associate. MBB 491 coursework includes preparation of a research proposal and a report and oral presentation on the results of the project. Prerequisite: MBB 308 or MBB 309W and permission of the MBB department. Upper level standing in an MBB major, minor or honours program is required.

MBB 492 is the second of two courses taken consecutively to fulfill the requirements of the MBB Honours program (Option B). Two-thirds of full-time laboratory research in an area of molecular biology or biochemistry. The research project is typically a continuation of the MBB 491 project, supervised by the same faculty member. The course includes the preparation of a research proposal, a report and an oral presentation on the results of the project. Prerequisite: MBB 491, MBB 308, MBB 309W and MBB 331, enrollment in the MBB honours program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the department.

Recent research articles on the molecular mechanisms underlying cellular activities, genomics and bioinformatics or the structure, function and interactions of macromolecules will be presented and discussed by students and faculty. This course will be available for MBB undergraduates to take once for undergraduate credit and will be offered in conjunction with MBB 821 (Cell and Molecular Biology), 841 (Genomics and Bioinformatics) or 861 Biomolecular Structure and Function. Prerequisite: Permission of the instructor.

MBB 481 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 481 encompasses the research design aspect of the project, consisting of the research proposal and honours thesis. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 482 and MBB 483.

MBB 482 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 482 encompasses the research performance aspect of the project. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 481 and MBB 483.

MBB 483 is one of three Directed Research courses taken concurrently to fulfill the requirements of the MBB Honours program (Option A). This course provides students with the opportunity to carry out full time laboratory research in molecular biology and biochemistry under the supervision of an MBB faculty member or associate. The grade for MBB 483 encompasses the defense component of the research project. Prerequisite: MBB 308, MBB 309W and MBB 331, enrollment in the MBB or Biological Physics Honours Program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the MBB department. Corequisite: MBB 481 and MBB 482.

Directed reading in a topic of molecular biology or biochemistry chosen in consultation with a supervisor. Before seeking approval for enrollment in this course, the student should have already obtained the agreement of a faculty member that he/she is willing to supervise the project, and have prepared a written proposal (of approximately one page) stating the nature of the directed reading topic. The course will include the preparation of a written term paper on the topic chosen. Prerequisite: MBB 231, with a minimum grade of C, and permission of the molecular biology and biochemistry department. Usually, upper level standing with at least 60 units in a Biochemistry major, minor or honours program will be required.

MBB 491 is offered as a stand-alone Directed Research course open to MBB Majors, or as the first of two courses taken consecutively to fulfill the requirements of the MBB Honours program (Option B). This course provides students with the opportunity to carry out part time laboratory research in an area of molecular biology or biochemistry under the supervision of an MBB faculty member or associate. MBB 491 coursework includes preparation of a research proposal and a report and oral presentation on the results of the project. Prerequisite: MBB 308 or MBB 309W and permission of the MBB department. Upper level standing in an MBB major, minor or honours program is required.

MBB 492 is the second of two courses taken consecutively to fulfill the requirements of the MBB Honours program (Option B). Two-thirds of full-time laboratory research in an area of molecular biology or biochemistry. The research project is typically a continuation of the MBB 491 project, supervised by the same faculty member. The course includes the preparation of a research proposal, a report and an oral presentation on the results of the project. Prerequisite: MBB 491, MBB 308, MBB 309W and MBB 331, enrollment in the MBB honours program, a minimum 3.0 CGPA and 3.0 UDGPA and permission of the department.

Part time laboratory research in an area of molecular biology or biochemistry under the supervision of an MBB faculty member or associate. MBB 498 coursework includes preparation of a research proposal, a report and an oral presentation on the results of the project. Prerequisite: MBB 308 or 309W; Students may not take MBB 498 concurrently with MBB 481, 482, 483, 491 or 492 or BISC 490, 491, 492W, 498 or 499.