911³Ô¹Ï

An introduction to the biochemical and physiological mechanisms of living organisms. Topics covered include cell structure and function, DNA replication and the flow of genetic information, enzyme function, metabolism and physiology of microorganisms, plants, and animals. Prerequisite: High school Biology 12 (or equivalent) with a C grade or better, or BISC 100 with C- or better, or BISC 113 with C+ or better, or HSCI 100 with C+ or better; and High school Chemistry 12 (or equivalent) with a C grade or better, or CHEM 111 with a C- or better. Breadth-Science.

Survey of the diversity of life, and its evolutionary history on earth. The student is introduced to the study of genetics, development, and evolution, giving an overview of how these processes interact to produce form and function. Also included are principles of behavior and ecological relationships of organisms to each other and their environment. Prerequisite: High school biology 12 (or equivalent) with a C grade or better, or BISC 100 with C- or better, or BISC 113 with C+ or better, or HSCI 100 with C+ or better. Breadth-Science.

Principles and concepts of the transmission of genetic information treated comparatively in man, animal, plant and microbe. Prerequisite: BISC 101 and 102 with a grade of C- or better.

Atomic and molecular structure; chemical bonding; thermochemistry; elements; periodic table; gases liquids, solids, and solutions. This course includes a laboratory component. Prerequisite: Chemistry 12 with a minimum grade of C, or CHEM 109 or 111 with a minimum grade of C-. Students with credit for CHEM 120 or 125 may not take this course for further credit. Quantitative/Breadth-Science.

Chemical equilibria; electrochemistry; chemical thermodynamics; kinetics. Students who intend to take further laboratory courses in chemistry should take CHEM 122 concurrently with CHEM 126. Prerequisite: CHEM 120 or 121 with a minimum grade of C-. Students with credit for CHEM 124 or CHEM 180 may not take this course for further credit. Quantitative.

Structure, bonding, physical and chemical properties of simple organic compounds. Introduction to spectroscopy. Kinetics and mechanisms of organic reactions. This course includes a laboratory component. Prerequisite: CHEM 121 with a minimum grade of C-. Corequisite: CHEM 122. Students with credit for CHEM 280 or CHEM 285 may not take this course for further credit. Quantitative.

Polyfunctional organic compounds and complex organic reactions. Introduction to natural products. Prerequisite: CHEM 281 with a minimum grade of C-. Students with credit for CHEM 283 may not take this course for further credit. Quantitative.

How health, illness and disease are defined and measured for individuals and populations. Research strategies used to identify how health, illness and disease are distributed across human populations and how environmental, socio-economic, demographic, biological, behavioural and political factors influence individual and population health. Breadth-Social Sci/Science.

Designed for students specializing in the biological and medical sciences. Topics include: limits, growth rate and the derivative; elementary functions, optimization and approximation methods, and their applications; mathematical models of biological processes. Prerequisite: Pre-Calculus 12 (or equivalent) with a grade of at least B, or MATH 100 with a grade of at least C, or achieving a satisfactory grade on the 911³Ô¹Ï Calculus Readiness Test. Students with credit for either MATH 150, 151 or 157 may not take MATH 154 for further credit. Quantitative.

Designed for students specializing in the biological and medical sciences. Topics include: the integral, partial derivatives, differential equations, linear systems, and their applications; mathematical models of biological processes. Prerequisite: MATH 150, 151 or 154; or MATH 157 with a grade of at least B. Students with credit for MATH 152 or 158 may not take this course for further credit. Quantitative.

The structure, function and synthesis of proteins, RNA and DNA and their interrelated biological functions within the cell. An introduction to molecular biology techniques and methods of protein purification and analysis. Prerequisite: or Corequisite CHEM 281.

A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. Modern techniques used in the analysis of organelle and cell function are integral parts of the course. Prerequisite: MBB 222, BISC 101, CHEM 281 with grades of C- or better. Corequisite or Prerequisite: CHEM 282 or CHEM 283.

Force and motion, conservation of energy and momentum, fluids, properties of soft matter and thermal physics with applications taken from the life sciences. Prerequisite: BC Principles of Physics 12 or PHYS 100 or equivalent, with a minimum grade of C-. This prerequisite may be waived, at the discretion of the department, as determined by the student's performance on a regularly scheduled PHYS 100 final exam. Please consult the physics advisor for further details. Corequisite: MATH 150 or 151 or 154 or 157; BISC 100 or 101 or 102. Recommended Corequisite: PHYS 132. Students with credit for PHYS 120, 125 or 140 may not take this course for further credit. Quantitative/Breadth-Science.

Research methodology and associated statistical analysis techniques for students with training in the life sciences. Intended to be particularly accessible to students who are not specializing in Statistics. Prerequisite: Recommended: 30 units. Students cannot obtain credit for STAT 201 if they already have credit for - or are taking concurrently - STAT 101, 203, 205, 285, or any upper division STAT course. Quantitative.

An interdisciplinary overview of the major non-communicable diseases - cancers, cardiovascular and metabolic diseases - from a public health perspective. Review of biological mechanisms, risk factors, historical and cultural contexts, and global distribution. Prerequisite: HSCI 100 or BISC 101, HSCI 130.

An integrated survey of infectious diseases and their social and economic causes and consequences. Infectious agents, including bacteria, protozoa, fungi and viruses -- how they spread, how they work, and how they can be stopped. Surveillance, prevention, and management of infectious diseases and epidemics. Prerequisite: HSCI 100 or BISC 101, HSCI 130.

An interdisciplinary overview of mental health and mental illness among populations. A review of the distribution and risk factors of mental illnesses as well as the historical and cultural context of their development. Prerequisite: HSCI 100 or BISC 101, HSCI 130.

Effects that social and ecological factors have on human growth, development and health. Challenges such as epidemics, natural catastrophes, industrialization, globalization, migration, poverty, war, global warming, etc, leading to evolution and adaptations. Relationships between socio-ecological challenges, their health consequences and related gene-population variations and effects on growth, development, sexual maturation, reproductive investment, and senescence and health. Prerequisite: HSCI 100 or BISC 101.

A comparative analysis of the Canadian health care financing and delivery systems and policies. History, organizational principles, health care resources, costs, access to care, quality, and equity. Societal and political issues, threats and values that affect Canada's health care system and others around the world. Prerequisite: 60 units, including nine HSCI units.

Practical ethical and legal issues in health sciences, emphasizing population and public health. Case studies approach highlighting current ethical dilemmas and decision-making in the context of global to local legal frameworks. Prerequisite: 45 units including nine HSCI units, one of which must be a 200 division course. HSCI 319 is identical to PHIL 319 and students cannot receive credit for both courses. Writing.

Molecular, cellular and systemic approach to examine topics in human pathophysiology. Prerequisite: MBB 231, or permission of the instructor.

Human variation and human health in the context of population genetics, epidemiology, demography, and human evolution. Prerequisite: BISC 202.

The concepts and measurements of human population dynamics in epidemiological inference. Identification of causes and prevalence of disease. Demographic and molecular methodology to assess the determinants of health and disease. Prerequisite: nine HSCI units including one HSCI 200 division course and either STAT 302 or 305 which may be taken concurrently.

The study of DNA and RNA in relation to gene structure and expression: DNA replication and the regulation of gene expression in bacteria and higher organisms. Introduction to recombinant DNA and cloning theory; natural vector structures and recombinant vector construction. Prerequisite: MBB 231, and BISC 202, with a minimum grade of C.

The standard techniques of multiple regression analysis, analysis of variance, and analysis of covariance, and their role in observational and experimental studies. This course may not be used to satisfy the upper division requirements of the Statistics major or honours program. Prerequisite: One of STAT 201, STAT 203, STAT 205, STAT 270, or BUEC 232. Quantitative.

Intermediate statistical techniques for the health sciences. Review of introductory concepts in statistics and probability including hypothesis testing, estimation and confidence intervals for means and proportions. Contingency tables and the analysis of multiple 2x2 tables. Correlation and regression. Multiple regression and model selection. Logistic regression and odds ratios. Basic concepts in survival analysis. This course may not be used to satisfy the upper division requirements of the Statistics major or honours program. Prerequisite: One of STAT 201, STAT 203, STAT 205, STAT 270, or BUEC 232. Quantitative.

Biological, molecular and biochemical actions of drugs and toxicants. Genetic and environmental risk determinants. Understanding the broad spectrum of toxicological problems encountered in clinical practice, drug development and regulation, and medical research. Prerequisite: MBB 231, CHEM 282.

Introduction to the structure and function of the immune system and how this system protects against microbial infections. Innate immune responses, including the function of innate immune cells, receptors and complement. Adaptive immune responses, including the organization of lymphoid organs, development and function of T and B cells, and antibodies. Prerequisite: MBB 231. Students with credit for HSCI 426, MBB 426 or MBB 326 may not take this course for further credit.

Animal virology in the context of viral diseases in humans and animals. Animal viruses, their replication, virus-host interactions and viral diseases. Prerequisite: MBB 222, or permission of the instructor. Corequisite: BISC 303.

Techniques in gene cloning and the evaluation of gene function are introduced in lectures and practiced in labs. Lab exercises include genomic DNA, RNA, and plasmid purification; PCR; various cloning techniques; and construction of novel genes. Students are introduced to additional techniques in lectures including gene editing, and genome sequencing. Prerequisite: BISC 202, MBB 222, and MBB 231, all with a grade of C- or better. Recommended: MBB 331. Students with credit for MBB 308 may not take this course for further credit.

Modern molecular biological and recombinant nucleic acid methods will be covered. Examples are DNA and RNA isolation, plasmid preparation, restriction enzyme digestion, DNA cloning and polymerase chain reaction. Prerequisite: or corequisite: MBB 331 with a minimum grade of C-. Students with credit for BISC 357 may not take this course for further credit.

Contemporary techniques in biochemistry including protein purification, immunochemical methods, and lipid characterization. Prerequisite: MBB 231, with a minimum grade of C. Recommended: CHEM 215 and CHEM 286 precede MBB 309W. Writing.

A review of pathophysiological mechanisms of disease with an emphasis on the molecular, cellular and genetic bases of pathology. Laboratory includes cell-biology experiments, histological preparations, and microscopic examination of normal and diseased tissues. Prerequisite: HSCI 321 and one of BISC 357, MBB 308, or MBB 309W.

Study, in a laboratory environment, of animal viruses as infectious agents that threaten human health as well as their use as biomedical tools. Includes cell culture methods, virus amplification, titration, purification, and identification, etc. Prerequisite: HSCI 338 and one of: BISC 303, BISC 357, MBB 308, or MBB 309.

Laboratory methods in immunology. Focus on the vertebrate immune system and the molecular and cellular principles underlying immune recognition. Experimental methods designed to combine serology, biochemistry, molecular biology, cell biology and genetics as a basis for understanding immunological aspects of health and disease. Prerequisite: HSCI 326 or MBB 326, and one of BISC 303, BISC 357, MBB 308, or MBB 309W.

Defects in the immunologic responses to bacterial, viral and parasitic infections. The mechanisms of action of vaccines. The causes of immune-mediated diseases, such as autoimmune diseases, hypersensitivity reactions (including asthma and allergy) and organ transplant rejection. The reaction of the immune system to cancer and immunotherapy for cancer. Prerequisite: MBB 326 or HSCI 326, with a minimum grade of C, or permission of the instructor. Students with credit for MBB 427 may not take this course for credit.

Mechanisms underlying viral infectious diseases in humans and animals at the levels of the molecule, cell, organ and the individual. Virus spread in a host, host responses to the viral infection, and virus-host interactions that result in disease. Prerequisite: HSCI 338 - Animal virology and HSCI 321- Human pathophysiology.

Mechanisms of drug action in the brain, including several classes of drugs and neurotransmitter systems that are involved in mental health disorders, drug addiction and neurodegeneration. Prerequisite: HSCI 323 and either HSCI 321 or MBB 331.

Discussion of novel and advanced topics in chemical covalent modifications of chromatin that influence gene regulation. Prerequisite: MBB 331, or permission of the instructor.

Current topics in molecular biology-based research into pathologies of disease related to drug and environmental exposures. Focus on systems pharmacology and the molecular determinants of drug and toxicant action as they relate to gene expression and signal transduction. Prerequisite: HSCI 323 and MBB 331, or permission of the instructor.

Immunological concepts of vaccines and vaccinology including vaccination, correlates of immune protection, humoral and mucosal immunity, adjuvants, recombinant vaccine technology, 'designer' vaccines, and HIV/AIDS vaccine design as a paradigm for modern vaccinology. Prerequisite: HSCI 326 or MBB 326, or HSCI 338, or permission of the instructor.

Application of modern molecular methods to epidemiological questions. Globally-relevant and emerging infectious diseases will be highlighted. Prerequisite: HSCI 330 and MBB 331 as pre- or co-requisites. Students with credit for HSCI 432 in 2010 may not complete HSCI 478 for further credit.

An in-depth overview of newly emerging and re-emerging infectious diseases in the context of disease prevention, surveillance and control. Prerequisite: HSCI 326 or MBB 326, or HSCI 338.